Pain is a complex perceptual phenomenon. Coordinated activity among local and distant brain networks is a central element of the neural underpinnings of pain. Brain oscillatory rhythms across diverse frequency ranges provide a functional substrate for coordinating activity across local neuronal ensembles and anatomically distant brain areas in pain networks. This review addresses parallels between insights from human and rodent analyses of oscillatory rhythms in acute and chronic pain and discusses recent rodent-based studies that have shed light on mechanistic underpinnings of brain oscillatory dynamics in pain-related behaviors. We highlight the potential for therapeutic modulation of oscillatory rhythms, and identify outstanding questions and challenges to be addressed in future research.

疼痛是一种复杂的知觉现象。局部和远距离大脑网络之间的协调活动是疼痛神经基础的核心要素。不同频率范围内的大脑振荡节律为协调局部神经元集合和疼痛网络中解剖学上较远的大脑区域的活动提供了功能基础。这篇综述讨论了人类和啮齿动物对急性和慢性疼痛振荡节律的分析之间的相似之处，并讨论了最近基于啮齿动物的研究，这些研究阐明了疼痛相关行为中大脑振荡动力学的机械基础。我们强调了振荡节律的治疗调节潜力，并确定了未来研究中需要解决的突出问题和挑战。