7T dynamic contrast-enhanced MRI for the detection of subtle blood–brain barrier leakage,Journal of Neuroimaging

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7T dynamic contrast-enhanced MRI for the detection of subtle blood–brain barrier leakage
Journal of Neuroimaging ( IF 2.4 ) Pub Date : 2021-06-23 , DOI: 10.1111/jon.12894
Lisanne P W Canjels _{1,

2,

3} , Jacobus F A Jansen _{1,

2,

3} , Marieke van den Kerkhof _{1,

2} , Robert-Jan Alers _{4,

5} , Benedikt A Poser ₆ , Christopher J Wiggins ₇ , Veronique M M M Schiffer _{4,

5} , Vincent van de Ven ₆ , Rob P W Rouhl _{2,

8,

9} , W M Palm ₁ , Robert J van Oostenbrugge _{2,

8,

10} , Albert P Aldenkamp _{2,

3,

8,

9} , Chahinda Ghossein-Doha _{5,

10,

11} , Marc E A Spaanderman _{4,

5} , Walter H Backes _{1,

2,

10}

Affiliation

Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.
MHENS, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Department of Gynecology and Obstetrics, Maastricht University Medical Center, Maastricht, the Netherlands.
GROW, School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.
Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Scannexus BV, Maastricht, the Netherlands.
Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.
Academic Center for Epileptology Kempenhaeghe/Maastricht UMC+, Heeze and Maastricht, the Netherlands.
CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.
Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands.

Dynamic contrast-enhanced MRI (DCE-MRI) can be employed to assess the blood–brain barrier (BBB) integrity. Detection of BBB leakage at lower field strengths (≤3T) is cumbersome as the signal is noisy, while leakage can be subtle. Utilizing the increased signal-to-noise ratio at higher field strengths, we explored the application of 7T DCE-MRI for assessing BBB leakage.

中文翻译：

7T 动态对比增强 MRI 检测细微血脑屏障渗漏

动态对比增强 MRI (DCE-MRI) 可用于评估血脑屏障 (BBB) 的完整性。在较低场强 (≤3T) 下检测 BBB 泄漏很麻烦，因为信号有噪声，而泄漏可能很微妙。利用在更高场强下增加的信噪比，我们探索了 7T DCE-MRI 在评估 BBB 泄漏方面的应用。

更新日期：2021-06-23

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