Obesity is closely linked with metabolic diseases, while life and prenatal exposure to endocrine-disrupting chemicals has been implicated in the development of obesity. Magnesium lithospermate B (MLB), an active compound of Salvia miltiorrhiza (Danshen), has beneficial effects on insulin resistance and metabolic abnormalities in diet-induced obese rodents. Since exposure to endocrine-disrupting chemical Bisphenol A (BPA) during pregnancy mimics the effects of high fat diet-induced alterations of glucose and lipid metabolism in adult male offspring, the effects of daily MLB supplementation for 4 weeks on metabolic abnormalities in rats weaning from prenatal BPA-exposed dams were investigated. BPA-exposed rats developed obesity and adiposity concurrent with hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia, and elevation of circulating glucagon and free fatty acids. Increased hepatic fatty acid synthesis and decreased fatty acid β-oxidation, activation of adipocytic adipogenesis, maturation, and lipogenesis, as well as reduction of muscular glucose uptake were demonstrated in BPA-exposed rats. The aforementioned alterations were improved by MLB supplementation. Additionally, MLB displayed negative effects on glucocorticoid receptor action and inflammation, and promoted lipolysis and thermogenesis in the adipose tissues. In conclusion, our findings suggest that MLB may be a potential therapeutic compound against metabolic diseases, including maternal exposure-induced metabolic abnormalities.

中文翻译：

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补充精镁 B 改善产前双酚 A 暴露引起的雄性后代代谢异常

肥胖与代谢疾病密切相关，而生命和产前暴露于内分泌干扰化学物质与肥胖的发展有关。Magnesium lithospermate B (MLB)，丹参（丹参）的活性化合物)，对饮食诱导的肥胖啮齿动物的胰岛素抵抗和代谢异常具有有益影响。由于在怀孕期间暴露于内分泌干扰化学物质双酚 A (BPA) 模拟了高脂肪饮食引起的成年雄性后代葡萄糖和脂质代谢改变的影响，因此每天补充 MLB 4 周对断奶大鼠代谢异常的影响对产前暴露于 BPA 的水坝进行了调查。暴露于 BPA 的大鼠出现肥胖和肥胖，同时伴有高血糖、高胰岛素血症、胰岛素抵抗、高甘油三酯血症以及循环胰高血糖素和游离脂肪酸升高。增加肝脏脂肪酸合成和减少脂肪酸β-氧化，激活脂肪细胞的脂肪生成、成熟和脂肪生成，以及在 BPA 暴露的大鼠中证明了肌肉葡萄糖摄取的减少。通过 MLB 补充剂改善了上述变化。此外，MLB 对糖皮质激素受体作用和炎症产生负面影响，并促进脂肪组织中的脂肪分解和产热。总之，我们的研究结果表明 MLB 可能是一种潜在的治疗代谢疾病的化合物，包括母体暴露引起的代谢异常。