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A preliminary study of the plasma concentrations of orally administered fluconazole in alpacas (Vicugna pacos)
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2021-06-24 , DOI: 10.1111/jvp.12994
Christine D Butkiewicz 1 , Lisa F Shubitz 1 , David E Nix 2
Affiliation  

Alpacas residing in the region endemic for Coccidioides spp. are susceptible to serious, disseminated coccidioidomycosis that may result in death. There is currently no oral antifungal dose recommendation for this species. We used a steady-state study design to assess the pharmacokinetics of oral generic fluconazole in alpacas dosed q 24 h for 14 days. Cohorts of 2–3 animals received fluconazole from 6 to 15 mg/kg/day, and pharmacokinetic analysis was performed after each group of animals in order to make dose adjustments for the next group. The final three animals were used as confirmation of our dose recommendation. The median Tmax was 7 h, and the median Cmax was 1.25 µg/ml per mg/kg dose. The mean dose-normalized 24-h AUC was 41.7 µg h/ml per mg/kg dose (CV = 72%). Based on these results, we recommend alpacas receive a starting dose of oral fluconazole at 10–15 mg/kg/day based on the fluconazole AUC in humans (313–625 µg h/ml). Testing to ascertain putative therapeutic plasma concentrations and monitoring of serum transaminases should be performed.

中文翻译:

羊驼(Vicugna pacos)口服氟康唑血浆浓度的初步研究

居住在球孢子虫流行地区的羊驼。易患严重的播散性球孢子菌病,可能导致死亡。目前没有针对该物种的口服抗真菌剂量推荐。我们使用稳态研究设计来评估口服通用氟康唑在羊驼中的药代动力学,每 24 小时给药 14 天。2-3 只动物的队列接受 6 至 15mg/kg/天的氟康唑,并在每组动物后进行药代动力学分析,以便为下一组进行剂量调整。最后三只动物被用作我们推荐剂量的确认。中位T max为 7 h,中位C max每毫克/公斤剂量为1.25微克/毫升。平均剂量标准化的 24 小时 AUC 为每 mg/kg 剂量 41.7 µg h/ml (CV = 72%)。基于这些结果,我们建议羊驼接受口服氟康唑的起始剂量为 10-15 mg/kg/天,基于人的氟康唑 AUC (313-625 µg h/ml)。应进行测试以确定推定的治疗性血浆浓度并监测血清转氨酶。
更新日期:2021-06-24
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