The Journal of Membrane Biology ( IF 2.4 ) Pub Date : 2021-06-24 , DOI: 10.1007/s00232-021-00189-8 Punita Aggarwal 1 , Sanjiv Singh 1 , V Ravichandiran 1
K2P channel is the leaky potassium channel that is critical to keep up the negative resting membrane potential for legitimate electrical conductivity of the excitable tissues. Recently, many substances and medication elements are discovered that could either straightforwardly or in a roundabout way influence the 15 distinctive K+ ion channels including TWIK, TREK, TASK, TALK, THIK, and TRESK. Opening and shutting of these channels or any adjustment in their conduct is thought to alter the pathophysiological condition of CNS. There is no document available till now to explain in detail about the molecular mechanism of agents acting on K2P channel. Accordingly, in this review we cover the current research and mechanism of action of these channels, we have also tried to mention the detailed effect of drugs and how the channel behavior changes by focusing on recent advances regarding activation and modulation of ion channels.
Graphic Abstract
中文翻译:
神经系统疾病中的双孔域钾通道
K2P 通道是泄漏的钾通道,对于保持负静息膜电位以实现可兴奋组织的合法导电性至关重要。最近,发现了许多物质和药物元素,它们可以直接或以迂回的方式影响 15 种独特的 K +离子通道包括 TWIK、TREK、TASK、TALK、THIK 和 TRESK。这些通道的打开和关闭或对其行为的任何调整都被认为会改变 CNS 的病理生理状况。到目前为止,还没有文献详细解释药物作用于 K2P 通道的分子机制。因此,在这篇综述中,我们涵盖了这些通道的当前研究和作用机制,我们还试图通过关注离子通道激活和调节的最新进展来提及药物的详细作用以及通道行为如何变化。