Seminars in Immunopathology ( IF 9 ) Pub Date : 2021-06-24 , DOI: 10.1007/s00281-021-00870-z E Mitre 1 , A D Klion 2
Since the earliest descriptions of this enigmatic cell, eosinophils have been implicated in both protective and pathogenic immune responses to helminth infection. Nevertheless, despite substantial data from in vitro studies, human infections, and animal models, their precise role in helminth infection remains incompletely understood. This is due to a number of factors, including the heterogeneity of the many parasites included in the designation “helminth,” the complexity and redundancy in the host immune response to helminths, and the pleiotropic functions of eosinophils themselves. This review examines the consequences of helminth-associated eosinophilia in the context of protective immunity, pathogenesis, and immunoregulation.
中文翻译:
嗜酸性粒细胞和蠕虫感染:保护性还是致病性?
自从对这种神秘细胞的最早描述以来,嗜酸性粒细胞就与对蠕虫感染的保护性和致病性免疫反应有关。然而,尽管来自体外研究、人类感染和动物模型的大量数据,它们在蠕虫感染中的确切作用仍然不完全清楚。这是由于多种因素造成的,包括“蠕虫”这一名称中包含的许多寄生虫的异质性、宿主对蠕虫的免疫反应的复杂性和冗余性,以及嗜酸性粒细胞本身的多效性功能。本综述在保护性免疫、发病机制和免疫调节的背景下检查蠕虫相关嗜酸性粒细胞增多的后果。