Since the emergence of the novel coronavirus, named COVID-19, researchers are looking for a treatment to stop the devastating pandemic. During these efforts, mesenchymal stem cells (MSCs), the potential next generation of therapeutic methods with wide application for diseases, have successfully controlled cytokine storm following the virus infection. However, the use of MSCs has been limited due to the ethical issues, immunogenicity, and genetic modifications. Therefore, exosomes were introduced as a suitable substitute for the MSCs. In the case of COVID-19 treatment, both MSCs and exosomes exert their beneficial effect mainly through the management of the cytokine storm. This study provided the underlying mechanisms for the effect of exosomes on COVID-19 treatment and presented several preclinical and clinical studies of exosomes for COVID-19 treatment.

中文翻译：

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用于 COVID-19 治疗的间充质干细胞衍生的外泌体、临床前和临床证据。

自从名为 COVID-19 的新型冠状病毒出现以来，研究人员正在寻找一种治疗方法来阻止这场毁灭性的大流行。在这些努力中，间充质干细胞 (MSCs) 是具有广泛应用的潜在下一代疾病治疗方法，已成功控制病毒感染后的细胞因子风暴。然而，由于伦理问题、免疫原性和基因改造，MSCs 的使用受到限制。因此，外泌体被引入作为 MSC 的合适替代品。在 COVID-19 治疗的情况下，MSCs 和外泌体主要通过细胞因子风暴的管理发挥其有益作用。