Background

Several studies noted that increased fasting blood glucose in hospital is associated with increasing mortality of acute coronary syndrome (ACS). We conducted a meta-analysis to assess the risk of mortality after ACS in patients who had fasting hyperglycemia (FH) in hospital.

Methods

We conducted searches on PubMed, Cochrane Library, Web of Science, and Embase for relevant studies published before August 31, 2019. We pooled odds ratios (OR) from individual studies using a random effects model. Data abstraction was conducted by two independent reviewers, and the meta-analysis was performed using Review Manager version 5.3.

Results

Eight studies were included into our research. Patients with FH showed a 3.09-fold (OR 3.09, CI 2.64–3.61; p < 0.00001) increased mortality of patients during admission compared with those who had normal fasting blood glucose (FBG). A statistically significant difference in post hospitalization mortality between patients with and without in-hospital FH was also detected (OR 3.40, CI 2.80–4.14; p < 0.00001).

Conclusions

The available evidence suggests that in-hospital FH could increase the risk of in-hospital and out-of-hospital (30-day and long-term) mortalities after ACS.

中文翻译：

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急性冠脉综合征后院内空腹高血糖和死亡风险增加：系统概述和荟萃分析

背景

几项研究指出，住院空腹血糖升高与急性冠状动脉综合征 (ACS) 的死亡率增加有关。我们进行了一项荟萃分析，以评估住院期间空腹高血糖 (FH) 患者发生 ACS 后的死亡风险。

方法

我们在 PubMed、Cochrane 图书馆、Web of Science 和 Embase 上搜索了 2019 年 8 月 31 日之前发表的相关研究。我们使用随机效应模型汇总了各个研究的优势比 (OR)。数据提取由两名独立审查员进行，荟萃分析使用 Review Manager 5.3 版进行。

结果

我们的研究包括八项研究。与 空腹血糖 (FBG) 正常的患者相比，FH患者在入院期间的死亡率增加了 3.09 倍（OR 3.09，CI 2.64–3.61；p < 0.00001）。还检测到院内 FH 患者与非院内 FH 患者的住院后死亡率存在统计学显着差异（OR 3.40，CI 2.80–4.14；p  < 0.00001）。

结论

现有证据表明，院内 FH 可能增加 ACS 后院内和院外（30 天和长期）死亡的风险。