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Sleep apnea and pulmonary hypertension: A riddle waiting to be solved
Pharmacology & Therapeutics ( IF 13.5 ) Pub Date : 2021-06-22 , DOI: 10.1016/j.pharmthera.2021.107935
Sunil Sharma 1 , Robert Stansbury 1 , Benjamin Hackett 1 , Henrik Fox 2
Affiliation  

Obstructive sleep apnea (OSA) is an under-recognized yet highly prevalent disease that has major implications to cardiovascular health. Pulmonary hypertension (pH) is less common but none the less a fatal condition. The association of OSA and PH is a known but not well understood phenomenon. Furthermore, the relationship appears to be bi-directional with limited understanding of the mechanism(s) driving the processes. PH in OSA has real time consequences as it has been shown to increase mortality. Limited data suggests that treatment with continuous positive pressure therapy may be beneficial and reduce pulmonary pressure. In this review, we discuss current data on prevalence of PH in OSA and vice versa. We also explore the pathophysiology of this relationship and a proposed mechanism for their connection. Finally, we address the treatment of OSA with CPAP and its impact on pulmonary pressures. Gaps in knowledge and future research potential are illustrated and discoursed.



中文翻译:

睡眠呼吸暂停和肺动脉高压:一个等待解开的谜团

阻塞性睡眠呼吸暂停 (OSA) 是一种未被充分认识但高度流行的疾病,对心血管健康有重大影响。肺动脉高压 (pH) 不太常见,但仍然是一种致命的疾病。OSA 和 PH 的关联是一种已知但尚未充分理解的现象。此外,这种关系似乎是双向的,对驱动过程的机制的理解有限。OSA 中的 PH 具有实时后果,因为它已被证明会增加死亡率。有限的数据表明,持续正压治疗可能是有益的并能降低肺压。在这篇综述中,我们讨论了有关 OSA 中 PH 患病率的当前数据,反之亦然。我们还探讨了这种关系的病理生理学以及它们之间的联系机制。最后,我们讨论了使用 CPAP 治疗 OSA 及其对肺压的影响。对知识差距和未来研究潜力进行了说明和讨论。

更新日期:2021-06-23
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