Introduction: Among persons with amnestic mild cognitive impairment (aMCI), intrusion errors on subscales that measure proactive semantic interference (PSI) may be among the earliest behavioral markers of elevated Alzheimer’s disease brain pathology. While there has been considerable cross-sectional work in the area, it is presently unknown whether semantic intrusion errors are predictive of progression of cognitive impairment in aMCI or PreMCI (not cognitively normal but not meeting full criteria for MCI). Methods: This study examined the extent to which the percentage of semantic intrusion errors (PIE) based on total responses on a novel cognitive stress test, the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), could predict clinical/cognitive outcomes over an average 26-month period in older adults initially diagnosed with aMCI, PreMCI, and normal cognition. Results: On the LASSI-L subscale sensitive to PSI, a PIE cut point of 44% intrusion errors distinguished between those at-risk individuals with PreMCI who progressed to MCI over time compared to individuals with PreMCI who reverted to normal on longitudinal follow-up. Importantly, PIE was able to accurately predict 83.3% of aMCI individuals who later progressed to dementia. Discussion: These preliminary findings indicate that PIE on LASSI-L subscales that measure PSI may be a useful predictor of clinical progression overtime in at-risk older adults.
Dement Geriatr Cogn Disord

中文翻译：

---

轻度认知障碍和 PreMCI 状态的老年人的侵入错误和认知缺陷进展

简介：在患有遗忘性轻度认知障碍 (aMCI) 的人中，测量主动语义干扰 (PSI) 的分量表上的侵入错误可能是阿尔茨海默病脑病理学升高的最早行为标志之一。虽然在该领域进行了大量的横断面研究，但目前尚不清楚语义侵入错误是否可以预测 aMCI 或 PreMCI 认知障碍的进展（认知不正常，但不符合 MCI 的全部标准）。方法：本研究根据新的认知压力测试 Loewenstein-Acevedo 语义干扰和学习量表 (LASSI-L) 的总反应，检查语义侵入错误 (PIE) 的百分比在多大程度上可以预测临床/认知结果最初诊断为 aMCI、PreMCI 和正常认知的老年人平均 26 个月。结果：在对 PSI 敏感的 LASSI-L 分量表上，44% 的侵入错误的 PIE 切点区分了随着时间推移进展为 MCI 的 PreMCI 高危个体与纵向随访恢复正常的 PreMCI 个体. 重要的是，PIE 能够准确预测 83.3% 的后来发展为痴呆的 aMCI 个体。讨论：这些初步研究结果表明，测量 PSI 的 LASSI-L 分量表上的 PIE 可能是高危老年人临床进展超时的有用预测指标。
痴呆老年认知障碍