The aim was to determine the effects of vatinoxan on dexmedetomidine plasma concentrations and effects on cardiovascular and intestinal tissue pharmacodynamics. In a prospective randomized study, six horses were premedicated intravenously with dexmedetomidine 3.5 µg kg⁻¹ followed by a constant-rate infusion of 7 µg kg⁻¹ h⁻¹ (group DEX) and six horses with dexmedetomidine of the same dose (bolus and constant-rate infusion) combined with vatinoxan 130 µg kg⁻¹ followed by 40 µg kg⁻¹ h⁻¹ (group VAT). Anaesthesia was induced with ketamine and diazepam and maintained with isoflurane. Venous blood samples were withdrawn before and at predefined points in time after drug application. During sedation and anaesthesia, cardiopulmonary variables, gastrointestinal tissue perfusion and oxygenation were recorded. Data were analysed using two-way-ANOVA, unpaired-t-test and Dunnett's-t-test (p < 0.05). Group VAT had significantly higher oxygen delivery and lower oxygen extraction ratio, venous admixture, alveolar dead space and alveolar-arterial-oxygen difference. Tissue perfusion of buccal mucosa was reduced during anaesthesia in group DEX. Plasma concentrations of dexmedetomidine in group VAT (n = 6) and group DEX (n = 5) were comparable between groups. In the present pilot study, co-administration of vatinoxan with dexmedetomidine did not alter plasma concentrations of dexmedetomidine but ameliorated tissue perfusion and global oxygenation variables.

中文翻译：

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右美托咪定加或不加伐替诺生作为恒速输注在异氟醚麻醉的马身上的药效学和血浆浓度——一项初步研究

目的是确定伐替诺生对右美托咪定血浆浓度的影响以及对心血管和肠道组织药效学的影响。在一项前瞻性随机研究中，六匹马预先用右美托咪定 3.5 µg kg ^-1静脉内给药，然后以 7 µg kg ^-1  h ^-1恒速输注（DEX 组）和六匹马用相同剂量的右美托咪定（推注和恒速输注）与伐替诺沙联合 130 µg kg ^-1然后是 40 µg kg ^-1  h ^-1（集团增值税）。用氯胺酮和地西泮诱导麻醉并用异氟醚维持。在药物应用之前和之后的预定时间点抽取静脉血样本。在镇静和麻醉期间，记录心肺变量、胃肠组织灌注和氧合。使用双向方差分析对数据进行分析，非配对t检验和Dunnett's-吨-test（p  <0.05）。组 VAT 具有显着更高的氧输送和更低的氧提取率、静脉混合、肺泡死腔和肺泡-动脉-氧气差异。DEX组麻醉时颊黏膜组织灌注减少。右美托咪定在 VAT 组 ( n  = 6) 和 DEX 组 ( n = 5) 组间具有可比性。在目前的初步研究中，伐替诺生与右美托咪定的共同给药不会改变右美托咪定的血浆浓度，但会改善组织灌注和整体氧合变量。