Cortical information has great importance to reflect the deep brain stimulation (DBS) effects for Parkinson’s disease patients. Using cortical activities to feedback is an available closed-loop idea for DBS. Previous studies have demonstrated the pathological beta (12–35 Hz) cortical oscillations can be suppressed by appropriate DBS settings. Thus, here we propose to close the loop of DBS based on the beta oscillations in cortex. By modify the cortico-basal ganglia-thalamic neural loop model, more biologically realistic underlying the Parkinsonian phenomenon is approached. Stimulation results show the proposed closed-loop DBS strategy using cortical beta oscillation as feedback information has more profound roles in alleviating the pathological neural abnormality than the traditional open-loop DBS. Additionally, we compare the stimulation effects with subthalamic nucleus feedback strategy. It is shown that using cortical beta information as the feedback signals can further enlarge the control parameter space based on proportional-integral control structure with a lower energy expenditure. This work may pave the way to optimizing the DBS effects in a closed-loop arrangement.

皮层信息对于反映帕金森病患者的深部脑刺激 (DBS) 效果具有重要意义。使用皮层活动进行反馈是 DBS 可用的闭环思路。以前的研究表明，适当的 DBS 设置可以抑制病理性 β (12–35 Hz) 皮质振荡。因此，我们在这里建议基于皮质中的 β 振荡关闭 DBS 循环。通过修改皮质-基底神经节-丘脑神经回路模型，可以更接近帕金森现象背后的生物学现实。刺激结果表明，与传统的开环 DBS 相比，所提出的以皮质 β 振荡作为反馈信息的闭环 DBS 策略在减轻病理性神经异常方面具有更深远的作用。此外，我们将刺激效果与底丘脑核反馈策略进行比较。结果表明，使用皮层β信息作为反馈信号可以进一步扩大基于比例-积分控制结构的控制参数空间，且能量消耗较低。这项工作可能为优化闭环安排中的 DBS 效应铺平道路。