The treatment of 2-(2-vinylphenyl)acetaldehydes or 3-(2-vinylphenyl)propanals with BF₃·Et₂O results in an intramolecular Prins reaction affording intermediary benzyl carbenium ions, which are then trapped by a variety of electron-rich aromatics via Friedel–Crafts alkylation. This cascade Prins/Friedel–Crafts cyclization protocol paves an expedient path to medicinally useful 4-aryltetralin-2-ol and 5-aryltetrahydro-5H-benzo[7]annulen-7-ol derivatives.

中文翻译：

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用于合成 4-aryltetralin-2-ols 和 5-aryltetrahydro-5H-benzo[7] annulen-7-ols 的级联分子内 Prins/Friedel-Crafts 环化

用 BF ₃ ·Et ₂ O处理 2-(2-乙烯基苯基) 乙醛或 3-(2-乙烯基苯基) 丙醛导致分子内 Prins 反应，提供中间的苄基碳正离子，然后被各种富电子捕获芳烃通过 Friedel-Crafts 烷基化。这种级联 Prins/Friedel-Crafts 环化方案为获得具有药用价值的 4-aryltetralin-2-ol 和 5-aryltetrahydro-5 H - benzo[7]annulen-7-ol 衍生物铺平了道路。