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pH-sensitive magnetic microcapsules for simultaneously controlled-releasing two drugs
International Journal of Polymeric Materials and Polymeric Biomaterials ( IF 3.2 ) Pub Date : 2021-06-21 , DOI: 10.1080/00914037.2021.1937161
Liwen Tang 1 , Ruiting Yang 1 , Haifang Liu 1, 2 , Ziyu Qin 1 , Bining Qiu 1 , Mengting Li 1 , Xueqiong Yin 1
Affiliation  

Abstract

pH-sensitive magnetic dual drug-loaded microcapsules (MDDM) embracing magnetic nanoparticles Fe3O4@SiO2 and two drugs (roxithromycin (ROX) and theophylline (TH)) were prepared through self-assembly, with methylcellulose and alginate sodium as the wall materials. MDDM was characterized with FTIR, XRD, TGA, vibrating sample magnetometer. The amount of Fe3O4@SiO2 affected the drug encapsulation efficiency lightly whereas affected the diameter of MDDM obviously. The drug loading of ROX and TH was 6.44% and 7.70% at the optimized conditions, respectively. The drug releasing of MDDM expressed obvious pH-sensitivity and increased with the pH value of the medium. The total cumulative release of ROX and TH in the simulative body fluid (pH 7.4) was 83.16% and 81.86% after 12 h, while was 24.54%, 21.21% in simulative gastric liquid. MDDM had higher antibacterial activity and lower cytotoxicity than the pure drugs with same amount, showing good capability on drug protection, controlled-releasing and toxicity elimination.



中文翻译:

两种药物同时控释的pH敏感磁性微胶囊

摘要

以甲基纤维素和海藻酸钠为载体,通过自组装制备了包含磁性纳米颗粒 Fe 3 O 4 @SiO 2和两种药物(罗红霉素(ROX)和茶碱(TH))的pH 敏感磁性双载药微胶囊(MDDM)墙体材料。用FTIR、XRD、TGA、振动样品磁力计对MDDM进行了表征。Fe 3 O 4 @SiO 2的量对药物包封率的影响较小,而对MDDM的直径影响明显。在优化条件下,ROX 和 TH 的载药量分别为 6.44% 和 7.70%。MDDM的药物释放表现出明显的pH敏感性,并随着介质pH值的升高而增加。12 h后,模拟体液(pH 7.4)中ROX和TH的总累积释放量分别为83.16%和81.86%,模拟胃液中为24.54%和21.21%。MDDM比等量的纯药具有更高的抗菌活性和更低的细胞毒性,表现出良好的药物保护、控释和毒性消除能力。

更新日期:2021-06-21
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