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Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidaemia and inflammation.
Journal of Lipid Research ( IF 6.5 ) Pub Date : 2021-06-16 , DOI: 10.1016/j.jlr.2021.100092
Sudip Paul 1 , Adam Alexander T Smith 2 , Kevin Culham 2 , Kevin A Gunawan 2 , Jacqueline M Weir 2 , Michelle A Cinel 2 , Kaushala S Jayawardana 2 , Natalie A Mellett 2 , Man K S Lee 3 , Andrew J Murphy 4 , Graeme I Lancaster 4 , Paul J Nestel 2 , Bronwyn A Kingwell 5 , Peter J Meikle 1
Affiliation  

Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases, hence increasing their levels might be beneficial in ameliorating these conditions. Shark liver oil (SLO) is a rich source of alkylglycerols that can be metabolised into plasmalogens. This study was designed to evaluate the impact of SLO supplementation on endogenous plasmalogen levels in individuals with features of metabolic disease. In this randomised, double-blind, placebo-controlled cross-over study, the participants (10 overweight or obese males) received 4 g Alkyrol® (purified SLO) or placebo (methylcellulose) per day for 3 weeks followed by a 3-week washout phase and were then crossed over to 3 weeks of the alternate placebo/Alkyrol® treatment. SLO supplementation led to significant changes in plasma and circulatory white blood cell lipidomes, notably increased levels of plasmalogens and other ether lipids. In addition, SLO supplementation significantly decreased the plasma levels of total free cholesterol, triglycerides and C-reactive protein. These findings suggest that SLO supplementation can enrich plasma and cellular plasmalogens, and this enrichment may provide protection against obesity-related dyslipidaemia and inflammation.

中文翻译:

鲨鱼肝油补充剂可丰富内源性缩醛磷脂并减少血脂异常和炎症的标志物。

缩醛磷脂是具有多种生物学功能的膜甘油磷脂。在代谢疾病中观察到缩醛磷脂水平降低,因此提高其水平可能有助于改善这些疾病。鲨鱼肝油 (SLO) 富含烷基甘油,可代谢成缩醛磷脂。本研究旨在评估补充 SLO 对具有代谢疾病特征的个体内源性缩醛磷脂水平的影响。在这项随机、双盲、安慰剂对照的交叉研究中,参与者(10 名超重或肥胖男性)每天服用 4 克 Alkyrol®(纯化的 SLO)或安慰剂(甲基纤维素),持续 3 周,随后服用 3 周洗脱期,然后交叉至 3 周的交替安慰剂/Alkyrol® 治疗。SLO 补充剂导致血浆和循环白细胞脂质组发生显着变化,显着增加缩醛磷脂和其他醚脂质的水平。此外,补充 SLO 显着降低了总游离胆固醇、甘油三酯和 C 反应蛋白的血浆水平。这些发现表明,补充 SLO 可以富集血浆和细胞缩醛磷脂,这种富集可以防止肥胖相关的血脂异常和炎症。
更新日期:2021-06-23
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