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Developing a radiochromic dosimeter for dosimetry in blood irradiation chambers
Radiation Physics and Chemistry ( IF 2.9 ) Pub Date : 2021-06-22 , DOI: 10.1016/j.radphyschem.2021.109637
Ebrahim Farajzadeh , Sedigheh Sina

Blood transfusion is known as a safe treatment, but it can sometimes be potentially dangerous. Despite careful examination, if the necessary precautions are not taken, blood transfusions can be unsafe for the recipient, and the risks can be fatal. Stable lymphocytes in blood products can cause fatal transplant reactions, and cause Transfusion-associated graft-versus-host disease, TA-GVHD. Prevention of this complication is possible only by direct irradiation of blood products before injection.

In this study, a Fricke Xylenol Gel (FXG) dosimeter with the effective atomic number of 7.3 and density of 1.05 g/cm3 has been proposed for accurate blood irradiation dosimetry. This dosimeter is a radiochromic chemical tissue-equivalent dosimeter, which can be read out by spectrophotometry. In addition, a simple and rapid method has been proposed to determine the absorbed dose in the FXG dosimeter, using a negatoscope, and a camera. The results show that the dosimeter developed in this study can be used in the dose range required for blood dosimetry, 5–50 Gy. The dosimetry process can be performed with an uncertainty of less than 5%. The results show that this dosimeter has the acceptable properties to control the dosimetry quality of blood radiation for the prevention of transplant complications against the host.



中文翻译:

开发用于血液辐照室剂量测定的放射变色剂量计

输血被认为是一种安全的治疗方法,但有时可能存在潜在危险。尽管仔细检查,如果不采取必要的预防措施,输血对接受者来说可能是不安全的,而且风险可能是致命的。血液制品中的稳定淋巴细胞会导致致命的移植反应,并导致输血相关的移植物抗宿主病,TA-GVHD。只有在注射前直接照射血液制品才能预防这种并发症。

在本研究中,使用有效原子序数为 7.3、密度为 1.05 g/cm 3的 Fricke Xylenol Gel (FXG) 剂量计已被提议用于准确的血液辐照剂量测定。本剂量计为放射变色化学组织等效剂量计,可通过分光光度法读出。此外,还提出了一种简单快速的方法来确定 FXG 剂量计中的吸收剂量,使用负镜和照相机。结果表明,本研究开发的剂量计可用于血液剂量测定所需的剂量范围,5-50 Gy。剂量测定过程可以以小于 5% 的不确定性进行。结果表明,该剂量计具有可接受的特性,可以控制血液辐射的剂量测定质量,以预防针对宿主的移植并发症。

更新日期:2021-06-28
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