Translumbosacral neuromodulation therapy (TNT) improves symptoms of fecal incontinence (FI), but its mechanism of action is unknown. We tested the hypothesis that TNT at one or more frequency will significantly improve underlying pathophysiology of FI through modulation of ascending and/or descending signaling pathways in the gut and brain axis and anorectal sensorimotor function.

中文翻译：

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经腰骶神经调节疗法对大便失禁患者肠脑相互作用和肛门直肠神经病变的影响：一项随机研究

经腰骶神经调节疗法 (TNT) 可改善大便失禁 (FI) 的症状，但其作用机制尚不清楚。我们测试了一个假设，即一个或多个频率的 TNT 将通过调节肠道和脑轴中的上行和/或下行信号通路以及肛门直肠感觉运动功能显着改善 FI 的潜在病理生理学。