Based on findings from adults with obsessive-compulsive disorder (OCD), this study examined alterations in resting-state functional connectivity (rs-fc) between the basolateral amygdala (BLA) and the ventromedial prefrontal cortex (vmPFC) in children and adolescents with OCD. We also assessed whether such BLA-vmPFC connectivity changed with or predicted response to exposure and response prevention (E/RP), the first-line treatment for pediatric OCD, given the involvement of these regions in fear processing, regulation, and extinction learning—a probable mechanism of action of E/RP.

中文翻译：

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改变的额-杏仁核功能连接可预测小儿强迫症对认知行为治疗的反应

基于来自患有强迫症 (OCD) 的成人的研究结果，本研究检查了患有强迫症的儿童和青少年的基底外侧杏仁核 (BLA) 和腹内侧前额叶皮层 (vmPFC) 之间的静息状态功能连接 (rs-fc) 的变化. 我们还评估了这种 BLA-vmPFC 连接是否会随着或预测对暴露和反应预防 (E/RP)（儿科强迫症的一线治疗）的反应而改变，因为这些区域参与了恐惧处理、调节和消退学习—— E / RP的可能作用机制。