In toxicology, standard sigmoidal concentration-response curves are used to predict effects concentrations and set chemical regulations. However, current literature also establishes the existence of complex, bimodal concentration-response curves, as is the case for arsenic toxicity. This bimodal response has been observed at the molecular level, but not characterized at the whole organism level. This study investigated the effect of arsenic (sodium arsenite) on post-gastrulated zebrafish embryos and elucidated effects of bimodal concentration-responses on different phenotypic perturbations.

中文翻译：

---

砷暴露引起斑马鱼的双峰毒性反应

在毒理学中，标准 S 形浓度响应曲线用于预测效应浓度并制定化学法规。然而，当前的文献也证实了复杂的双峰浓度-反应曲线的存在，砷中毒的情况就是如此。这种双峰反应已在分子水平上观察到，但尚未在整个生物体水平上进行表征。本研究调查了砷（亚砷酸钠）对原肠胚形成后斑马鱼胚胎的影响，并阐明了双峰浓度反应对不同表型扰动的影响。