Increased integration between default mode and task-relevant networks in children with ADHD is associated with impaired response control,Developmental Cognitive Neuroscience

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Increased integration between default mode and task-relevant networks in children with ADHD is associated with impaired response control
Developmental Cognitive Neuroscience ( IF 4.7 ) Pub Date : 2021-06-22 , DOI: 10.1016/j.dcn.2021.100980
Kelly A Duffy ₁ , Keri S Rosch ₂ , Mary Beth Nebel ₃ , Karen E Seymour ₄ , Martin A Lindquist ₅ , James J Pekar ₆ , Stewart H Mostofsky ₇ , Jessica R Cohen ₈

Affiliation

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Default mode network (DMN) dysfunction is theorized to play a role in attention lapses and task errors in children with attention-deficit/hyperactivity disorder (ADHD). In ADHD, the DMN is hyperconnected to task-relevant networks, and both increased functional connectivity and reduced activation are related to poor task performance. The current study extends existing literature by considering interactions between the DMN and task-relevant networks from a brain network perspective and by assessing how these interactions relate to response control. We characterized both static and time-varying functional brain network organization during the resting state in 43 children with ADHD and 43 age-matched typically developing (TD) children. We then related aspects of network integration to go/no-go performance. We calculated participation coefficient (PC), a measure of a region’s inter-network connections, for regions of the DMN, canonical cognitive control networks (fronto-parietal, salience/cingulo-opercular), and motor-related networks (somatomotor, subcortical). Mean PC was higher in children with ADHD as compared to TD children, indicating greater integration across networks. Further, higher and less variable PC was related to greater commission error rate in children with ADHD. Together, these results inform our understanding of the role of the DMN and its interactions with task-relevant networks in response control deficits in ADHD.

中文翻译：

ADHD 儿童默认模式和任务相关网络之间的整合增加与反应控制受损有关

从理论上讲，默认模式网络 (DMN) 功能障碍在注意力缺陷/多动障碍 (ADHD) 儿童的注意力缺失和任务错误中起作用。在 ADHD 中，DMN 与任务相关网络高度连接，增加的功能连接和减少的激活都与较差的任务性能有关。当前的研究通过从大脑网络的角度考虑 DMN 和任务相关网络之间的相互作用，并通过评估这些相互作用与反应控制的关系，扩展了现有文献。我们表征了 43 名 ADHD 儿童和 43 名年龄匹配的典型发育 (TD) 儿童在静息状态下的静态和时变功能性大脑网络组织。然后，我们将网络集成的各个方面与通过/不通过性能相关联。我们计算了参与系数（PC），一个区域网络间连接的度量，用于 DMN 区域、典型认知控制网络（额顶叶、突出/扣带盖）和运动相关网络（躯体运动、皮层下）。与 TD 儿童相比，ADHD 儿童的平均 PC 更高，表明跨网络的整合程度更高。此外，更高和更小的 PC 与 ADHD 儿童更高的佣金错误率有关。总之，这些结果让我们了解了 DMN 的作用及其与任务相关网络在 ADHD 反应控制缺陷中的相互作用。与 TD 儿童相比，ADHD 儿童的平均 PC 更高，表明跨网络的整合程度更高。此外，更高和更小的 PC 与 ADHD 儿童更高的佣金错误率有关。总之，这些结果让我们了解了 DMN 的作用及其与任务相关网络在 ADHD 反应控制缺陷中的相互作用。与 TD 儿童相比，ADHD 儿童的平均 PC 更高，表明跨网络的整合程度更高。此外，更高和更小的 PC 与 ADHD 儿童更高的佣金错误率有关。总之，这些结果让我们了解了 DMN 的作用及其与任务相关网络在 ADHD 反应控制缺陷中的相互作用。

更新日期：2021-07-12

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