ABSTRACT

Introduction

It is fortunate that an international panel of experts proposed definitions for multidrug-resistant (MDR) and extensively drug-resistant (XDR) in the past.

Areas covered

In our opinion, these definitions need amendments in order to be semantically more accurate.

Expert opinion

We suggest for the MDR definition to add to ‘MDR is defined as non-susceptibility to at least one agent in three or more antimicrobial categories’ that this non-susceptibility is at most to the total number of all antimicrobial categories minus two, so that the definition reads: MDR is defined as non-susceptibility to at least one agent in three or more antimicrobial categories and up to (and including) the total number of all antimicrobial categories minus two. We suggest that the experts’ definition of XDR as ‘non-susceptibility to at least one agent in all but two or fewer antimicrobial categories (i.e. bacterial isolates remain susceptible to only one or two categories)’ has to be modified regarding the content of the parenthesis to: (i.e. bacterial isolates remain susceptible to only one or two or even none antimicrobial category [in this latter setting bacterial isolates are resistant to at least one antimicrobial agent in all antimicrobial categories and concurrently there is at least one antimicrobial agent to which the isolate is susceptible to]).

中文翻译：

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关于多重耐药菌和广泛耐药菌定义的拟议修正案

摘要

介绍

幸运的是，一个国际专家小组在过去提出了多重耐药（MDR）和广泛耐药（XDR）的定义。

涵盖的领域

我们认为，这些定义需要修改，以便在语义上更准确。

专家意见

我们建议将 MDR 定义添加到“MDR 被定义为对三个或更多抗菌药物类别中的至少一种药物不敏感”，这种不敏感性最多为所有抗菌药物类别的总数减去 2，以便定义如下： 耐多药被定义为对三个或更多抗菌药物类别中的至少一种药物不敏感，并且不超过（并包括）所有抗菌药物类别的总数减去 2。我们建议专家将 XDR 定义为“对除两种或更少的抗菌药物类别中的至少一种药物不敏感（即细菌分离物仍然对一种或两种类别的药物敏感）”必须根据其内容进行修改。括号：（即