Ischemic stroke is a life-threatening disease with limited therapeutic strategies. Blood-brain barrier (BBB) disruption is a critical pathological process that contributes to poor outcomes in ischemic stroke. We previously showed that the microglial inhibition of the inflammasome sensor absent in melanoma 2 (AIM2) suppressed the inflammatory response and protected against ischemic stroke. However, whether AIM2 is involved in BBB disruption during cerebral ischemia is unknown.

中文翻译：

---

AIM2缺失增强实验性缺血性中风的血脑屏障完整性

缺血性中风是一种威胁生命的疾病，治疗策略有限。血脑屏障 (BBB) 破坏是导致缺血性中风预后不良的关键病理过程。我们之前表明，黑色素瘤 2 (AIM2) 中不存在的炎症小体传感器的小胶质细胞抑制抑制了炎症反应并防止缺血性中风。然而，AIM2 是否参与脑缺血期间的 BBB 破坏尚不清楚。