Abstract

A variety of azolyl pyrimidinyl acetamides were prepared from azolyl glycinate and 4,6-diaryl/heteroarylpyrimidinyl-2-amines in the presence of DMAP under ultrasonication. Nitrophenyl, pyridinyl and indolyl substituted thiazolyl pyrimidinyl acetamides (9c, 9e, 9f) and imidazolyl pyrimidinyl acetamides (10c, 10e, 10f) showed excellent antibacterial activity against B. subtilis and MBC is 2xMIC. The compounds 9c, 10c and 10e also showed excellent antifungal activity against A. niger and MFC is 2xMIC.

中文翻译：

---

唑基嘧啶基乙酰胺的合成及抗菌活性

摘要

以甘氨酸唑基和4,6-二芳基/杂芳基嘧啶基-2-胺为原料，在DMAP存在下，超声处理制备了多种唑基嘧啶基乙酰胺。硝基苯基、吡啶基和吲哚基取代的噻唑基嘧啶基乙酰胺（9c、9e、9f）和咪唑基嘧啶基乙酰胺（10c、10e、10f ）对枯草芽孢杆菌表现出优异的抗菌活性，MBC 为 2xMIC。化合物9c、10c和10e也显示出优异的抗黑曲霉活性，MFC为2xMIC。