Nanotechnology is spanning multiple fields of study from materials science to computer engineering and drug discovery. Since the early 21st century, nanotechnology and nano-enabled research have received great attention and governmental funding accompanied with interest to ensure human and environmental safety of engineered nanomaterials (ENMs). Optimal functioning of the cardiovascular (CV) system is of utmost importance for the overall health of the body. Following exposure, ENMs essentially end up in the circulation (at least partially) and hence it is key to assess any associated adverse CV consequences. Accumulating research suggests that exposure to ENMs (different compositions and physicochemical properties) has the capacity to directly and indirectly interact with CV components resulting in adverse events and worsening of CV complications. However, the underlying molecular mechanisms driving these events remain to be elucidated. In this article, we review state-of-art literature on ENM-associated adverse CV responses and discuss the potential underlying molecular mechanisms.

纳米技术跨越了从材料科学到计算机工程和药物发现的多个研究领域。自 21 世纪初以来，纳米技术和纳米技术研究受到了极大的关注和政府资助，同时也有兴趣确保工程纳米材料 (ENM) 的人类和环境安全。心血管 (CV) 系统的最佳功能对身体的整体健康至关重要。暴露后，ENM 基本上最终进入循环（至少部分），因此评估任何相关的不良心血管后果是关键。越来越多的研究表明，接触 ENM（不同的成分和物理化学性质）能够直接和间接地与 CV 成分相互作用，从而导致不良事件和 CV 并发症的恶化。然而，驱动这些事件的潜在分子机制仍有待阐明。在本文中，我们回顾了有关 ENM 相关不良 CV 反应的最新文献，并讨论了潜在的潜在分子机制。