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Diagnostic utility of flow cytometry based coated-platelets assay as a biomarker to predict thrombotic or hemorrhagic phenotype in acute stroke
Cytometry Part B: Clinical Cytometry ( IF 3.4 ) Pub Date : 2021-06-21 , DOI: 10.1002/cyto.b.22026
Rutvi Gautam Dave 1 , Tulasi Geevar 1 , Sanjith Aaron 2 , Rohit Ninan Benjamin 2 , Joy Mammen 1 , Snehil Kumar 1 , Ramya Vijayan 1 , Mahasampath Gowri 3 , Sukesh C Nair 1
Affiliation  

Coated-platelets are sub-population of platelets “coated” with highly procoagulant proteins and phosphatidylserine that sustains thrombin generation. They are produced upon dual agonist stimulation by collagen and thrombin. This study was conducted to assess if there was any difference in the levels of coated-platelets in patients with primary intracranial hemorrhage (PICH) and ischemic stroke due to large artery atherosclerosis (LAA) as compared to healthy controls, and to see if coated-platelet levels had any influence on the hemorrhagic transformation (HT) of ischemic stroke.

中文翻译:

基于流式细胞仪的涂层血小板测定作为预测急性卒中血栓形成或出血表型的生物标志物的诊断效用

包被血小板是“包被”高促凝蛋白和维持凝血酶生成的磷脂酰丝氨酸的血小板亚群。它们是在胶原蛋白和凝血酶的双重激动剂刺激下产生的。本研究旨在评估原发性颅内出血 (PICH) 和大动脉粥样硬化 (LAA) 所致缺血性卒中患者的涂层血小板水平与健康对照组相比是否存在差异,并观察涂层血小板水平是否存在差异。血小板水平对缺血性卒中的出血性转化(HT)有任何影响。
更新日期:2021-06-21
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