A series of 1,4-disubstituted digold–alkynyl complexes, [(PPh₃)Au]₂(μ-C≡C–Ar–CH≡C)], in which the 1,4-diethenylbenzene bridge contains two alkyl or oligo(ethylene glycol)methylether side chains at different positions (2,5- and 2,3-positions), have been synthesized and structurally characterized by spectroscopic techniques. The structure of [(AuPPh₃)₂{µ-C≡C–C₆H₂(OC₆H₁₃)₂-2,5-C≡C}] (2c) has been established by X-ray crystallography. Their antitumor activities in vitro were investigated by MTT assay against four tumor cell lines. Compared to alkyl-functionalized complexes, the oligo(ethylene glycol)methylether-functionalized complexes showed significant antitumor activity, which may be attributed to the improvement of the hydrophilicity of the complex to achieve the appropriate lipophilicity. In particular, complex [(AuPPh₃)₂{µ-C≡C–C₆H₂(OCH₂CH₂OCH₂CH₂OCH₃)₂-2,3-C≡C}] (2j) displayed high activity against the A549 cell line and low cytotoxicity toward normal cell lines. Notably, further investigations are required if complex 2j is to undergo trials as a new potential antitumor agent.

一系列 1,4-二取代二金-炔基配合物 [(PPh ₃ )Au] ₂ ( μ -C≡C – Ar-CH≡C)]，其中 1,4-二乙烯基苯桥包含两个烷基或寡聚不同位置（2,5-和2,3-位）的（乙二醇）甲基醚侧链已被合成并通过光谱技术进行结构表征。[(AuPPh ₃ ) ₂ {µ-C≡C–C ₆ H ₂ (OC ₆ H ₁₃ ) ₂ -2,5-C≡C}] ( 2c) 已通过 X 射线晶体学确定。通过对四种肿瘤细胞系的 MTT 测定研究了它们的体外抗肿瘤活性。与烷基官能化配合物相比，低聚（乙二醇）甲基醚官能化配合物显示出显着的抗肿瘤活性，这可能是由于提高了配合物的亲水性以达到适当的亲脂性。特别地，络合物 [(AuPPh ₃ ) ₂ {µ-C≡C–C ₆ H ₂ (OCH ₂ CH ₂ OCH ₂ CH ₂ OCH ₃ ) ₂ -2,3-C≡C}] ( 2j) 对 A549 细胞系显示出高活性，对正常细胞系显示出低细胞毒性。值得注意的是，如果将复合物2j作为一种新的潜在抗肿瘤剂进行试验，则需要进一步研究。