Objectives

Trophoblastic invasion at the maternal-fetal interface can affect pregnancy outcomes. To describe an intuitive theme trends and knowledge structure of trophoblastic invasion-related literature from a bibliometric perspective, and provide researchers with new research hotspots.

Study design

The literature form PubMed database related to trophoblastic invasion from January 1, 2012 to April 30, 2021 were extracted, and then biclustering analysis, co-word analysis, strategy diagram and social network analysis were performed to provide immature, or newly emerging research hotspots for researchers.

Results

A total of 96 high-frequency medical subjects heading terms were extracted and classified into 6 clusters. Themes in the first and second quadrant of strategy diagram, including trophoblasts metabolism, placenta metabolism, pre-eclampsia, etc., as the mature parts of the research on trophoblastic invasion have been well developed. On the other hand, themes in the third and fourth quadrants of strategy diagram, such as embryo implantation and trophoblasts immunology, pregnancy complication, matrix metalloproteinase and trophoblasts metabolism, habitual abortion and trophoblasts metabolism, etc., are immature themes. Social network analysis suggests that themes at the edge, such as habitual abortion / metabolism, placenta / immunology, natural killer cells / physiology, natural killer cells / immunology, embryo implantation / immunology, are considered new research hotspots and have considerable research space.

Conclusion

By analyzing the research hotspots related to trophoblastic invasion, immature themes and emerging hotspots deserve more attention and can be considered as hints when launching new research projects.

中文翻译：

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绘制滋养层入侵的主题趋势和知识结构，2012-2021 年的文献计量分析

目标

母胎界面的滋养细胞侵入会影响妊娠结局。从文献计量学的角度描述一个直观的滋养细胞入侵相关文献的主题趋势和知识结构，为研究人员提供新的研究热点。

学习规划

提取2012年1月1日至2021年4月30日PubMed数据库中滋养细胞侵袭相关的文献，然后进行双聚类分析、共词分析、策略图和社交网络分析，以提供不成熟或新兴的研究热点。研究人员。

结果

共提取了 96 个高频医学主题词，分为 6 个聚类。策略图第一象限和第二象限的主题，包括滋养细胞代谢、胎盘代谢、先兆子痫等，作为滋养细胞侵袭研究的成熟部分已经得到了很好的发展。另一方面，策略图第三和第四象限的主题，如胚胎着床与滋养层免疫学、妊娠并发症、基质金属蛋白酶与滋养层代谢、习惯性流产与滋养层代谢等，都是不成熟的主题。社交网络分析表明边缘主题，例如习惯性流产/新陈代谢、胎盘/免疫学、自然杀伤细胞/生理学、自然杀伤细胞/免疫学、胚胎植入/免疫学、

结论

通过对滋养层入侵相关研究热点的分析，不成熟的主题和新兴热点值得更多关注，可以作为开展新研究项目的提示。