当前位置: X-MOL 学术Int. J. Hyperth. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Ultrasound-guided thermal ablation for papillary thyroid microcarcinoma: a multicenter retrospective study
International Journal of Hyperthermia ( IF 3.1 ) Pub Date : 2021-06-21 , DOI: 10.1080/02656736.2021.1936218
Xiao-Jing Cao 1 , Ming-An Yu 1 , Ya-Lin Zhu 2 , Lu Qi 3 , Zhi-Bin Cong 4 , Guo-Zhen Yan 5 , Juan Liu 6 , Hong-Ling Wang 7 , Geng Liu 8 , Jian-Qin Guo 9 , Ying Hao 10 , Zhong-Hua Wang 11 , Xue Wang 4 , Jun-Feng He 5 , Aini Shataer 7 , Xiao-Fang Liu 10 , Zhen-Long Zhao 1 , Ying Wei 1 , Li-Li Peng 1 , Yan Li 1 , Shu-Rong Wang 3, 12 , Ying Che 2
Affiliation  

Abstract

Purpose

Ultrasound-guided thermal ablation (including microwave ablation [MWA] and radiofrequency ablation [RFA]) has emerged as a remarkable technology for the treatment of benign and malignant diseases. The objective of this multicenter study was to assess the efficacy and safety of thermal ablation in a large cohort of patients with papillary thyroid microcarcinoma (PTMC).

Materials and methods

Retrospective study of 725 patients who underwent MWA/RFA at 11 centers between March 2015 and March 2020. The mean age of patients was 46 ± 11 years (range, 22–81); the mean follow-up time was 21 ± 13 months (range, 6–60). Changes in size of tumor, the rates of tumor disappearance, disease progression, and complications were assessed.

Results

From 6 months post-ablation, the size of tumors was significantly reduced compared with those recorded pre-ablation (p < 0.001 for all). Five hundred and fifteen (71.0%) PTMCs had completely disappeared as assessed by ultrasound examination. Six (0.8%) patients developed disease progression post-ablation; of these, 5 (0.7%) patients developed new PTMCs, while one (0.1%) patient developed cervical lymph node metastasis. Nineteen (2.6%) patients developed complications post-ablation; of these 14 (1.9%) patients developed voice hoarseness, 4 (0.6%) developed hematoma, and one (0.1%) patient developed cough.

Conclusions

Ultrasound-guided thermal ablation represents an effective and safe treatment for patients with PTMC besides active surveillance and surgery.



中文翻译:

超声引导下甲状腺微小乳头状癌热消融:一项多中心回顾性研究

摘要

目的

超声引导热消融(包括微波消融 [MWA] 和射频消融 [RFA])已成为治疗良性和恶性疾病的卓越技术。这项多中心研究的目的是评估热消融在一大群甲状腺微小乳头状癌 (PTMC) 患者中的有效性和安全性。

材料和方法

对 2015 年 3 月至 2020 年 3 月期间在 11 个中心接受 MWA/RFA 的 725 名患者进行的回顾性研究。患者的平均年龄为 46 ± 11 岁(范围,22-81 岁);平均随访时间为 21 ± 13 个月(范围,6-60)。评估肿瘤大小、肿瘤消失率、疾病进展和并发症的变化。

结果

从消融后 6 个月起,与消融前记录的肿瘤大小相比,肿瘤大小显着减小( 所有p < 0.001)。通过超声检查评估,515 个 (71.0%) PTMC 已完全消失。6 名 (0.8%) 患者在消融后出现疾病进展;其中,5 名 (0.7%) 患者出现了新的 PTMC,而 1 名 (0.1%) 患者出现了颈部淋巴结转移。19 名 (2.6%) 患者在消融后出现并发症;这 14 名 (1.9%) 患者出现声音嘶哑,4 名 (0.6%) 出现血肿,1 名 (0.1%) 患者出现咳嗽。

结论

除了主动监测和手术外,超声引导下的热消融是 PTMC 患者的一种有效且安全的治疗方法。

更新日期:2021-06-21
down
wechat
bug