Tetraaryladamantanes have proven useful as chaperones for the co-crystallization of small molecules that do not readily crystallize by themselves. The co-crystals are often useful for structure elucidation. Usually, the small molecules are encapsulated in the crystal lattice of the aryladamantane that forms during rapid thermal crystallization. Thus far, co-crystallization has been limited to liquids as guest molecules. Here we report the co-crystal structures of phenol, which is solid at room temperature, with both 1,3,5,7-tetrakis(2,4-dimethoxyphenyl)adamantane (TDA) and 1,3,5,7-tetrakis(2,4-diethoxyphenyl)adamantane (TEO). The co-crystals were obtained from solutions in dichloromethane by slow evaporation or diffusion. The implications for generating other co-crystals of two solids are briefly discussed.

中文翻译：

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室温下有机固体和四芳基金刚烷的共结晶

四芳基金刚烷已被证明可用作分子伴侣，用于不易自行结晶的小分子的共结晶。共晶通常可用于结构解析。通常，小分子被封装在快速热结晶过程中形成的芳基金刚烷的晶格中。迄今为止，共结晶仅限于作为客体分子的液体。在这里，我们报告了室温下为固体的苯酚的共晶结构，与 1,3,5,7-四（2,4-二甲氧基苯基）金刚烷（TDA）和 1,3,5,7-四(2,4-二乙氧基苯基)金刚烷 (TEO)。通过缓慢蒸发或扩散从二氯甲烷溶液中获得共晶。简要讨论了产生两种固体的其他共晶的意义。