ABSTRACT

Influenza is a respiratory viral infection that causes significant morbidity and mortality worldwide. The innate immune cell response elicited during influenza A virus (IAV) infection forms the critical first line of defense, which typically is impaired as we age. As such, elderly individuals more commonly succumb to influenza-associated complications, which is reflected in most aged animal models of IAV infection. Here, we review the important roles of several major innate immune cell populations in influenza pathogenesis, some of which being deleterious to the host, and the current knowledge of how age-associated numerical, phenotypic and functional cell changes impact disease development. Further investigation into age-related modulation of innate immune cell responses, using appropriate animal models, will help reveal how immunity to IAV may be compromised by aging and inform the development of novel therapies, tailored for use in this vulnerable group.

摘要

流感是一种呼吸道病毒感染，在全球范围内导致严重的发病率和死亡率。在甲型流感病毒 (IAV) 感染期间引发的先天免疫细胞反应形成了关键的第一道防线，随着年龄的增长，这通常会受到损害。因此，老年人更容易死于流感相关并发症，这反映在大多数 IAV 感染的老年动物模型中。在这里，我们回顾了几种主要的先天免疫细胞群在流感发病机制中的重要作用，其中一些对宿主有害，以及目前关于与年龄相关的数量、表型和功能性细胞变化如何影响疾病发展的知识。使用适当的动物模型进一步研究与年龄相关的先天免疫细胞反应调节，