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Novel therapeutics for hydrocephalus: Insights from animal models
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2021-06-20 , DOI: 10.1111/cns.13695
Chuansen Wang 1, 2, 3 , Xiaoqiang Wang 4 , Changwu Tan 1, 2, 3 , Yuchang Wang 1, 2, 3 , Zhi Tang 5 , Zhiping Zhang 1, 2, 3 , Jingping Liu 1, 2, 3 , Gelei Xiao 1, 2, 3
Affiliation  

Hydrocephalus is a cerebrospinal fluid physiological disorder that causes ventricular dilation with normal or high intracranial pressure. The current regular treatment for hydrocephalus is cerebrospinal fluid shunting, which is frequently related to failure and complications. Meanwhile, considering that the current nonsurgical treatments of hydrocephalus can only relieve the symptoms but cannot eliminate this complication caused by primary brain injuries, the exploration of more effective therapies has become the focus for many researchers. In this article, the current research status and progress of nonsurgical treatment in animal models of hydrocephalus are reviewed to provide new orientations for animal research and clinical practice.

中文翻译:

脑积水的新疗法:来自动物模型的见解

脑积水是一种脑脊液生理疾病,导致脑室扩张,颅内压正常或偏高。目前脑积水的常规治疗方法是脑脊液分流术,这往往与失败和并发症有关。同时,考虑到目前脑积水的非手术治疗只能缓解症状,不能消除原发性脑损伤引起的并发症,探索更有效的治疗方法成为许多研究人员关注的焦点。本文就脑积水动物模型非手术治疗的研究现状和进展进行综述,为动物研究和临床实践提供新的方向。
更新日期:2021-08-05
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