Patients suffering from polycystic liver disease (PLD) can develop large liver volumes, leading to physical and psychological complaints, reducing quality of life. There is an unmet need for new therapies in these patients. Estrogen seems to be a promising target for new therapies. In this review, we summarize the available experimental and epidemiological evidence to unravel the role of estrogens and other female hormones in PLD, to answer clinical questions and identify new targets for therapy.

中文翻译：

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多囊肝中的雌激素：未来治疗的目标？

患有多囊性肝病 (PLD) 的患者可能会出现大量肝脏体积，导致身体和心理不适，从而降低生活质量。这些患者对新疗法的需求未得到满足。雌激素似乎是新疗法的一个有希望的目标。在这篇综述中，我们总结了现有的实验和流行病学证据，以阐明雌激素和其他女性激素在 PLD 中的作用，回答临床问题并确定新的治疗靶点。