Artemisinins are a family of sesquiterpene lactones originally derived from the sweet wormwood (Artemisia annua). Beyond their well-characterized role as frontline antimalarial drugs, artemisinins have also received increased attention for other potential pharmaceutical effects, which include antiviral, antiparsitic, antifungal, anti-inflammatory, and anticancer activities. With concerted efforts in further preclinical and clinical studies, artemisinin-based drugs have the potential to be viable treatments for a great variety of human diseases. Here, we provide a comprehensive update on recent reports of pharmacological actions and applications of artemisinins outside of their better-known antimalarial role and highlight their potential therapeutic viability for various diseases.

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青蒿素药物再利用的近期药理学进展

青蒿素是一种倍半萜内酯家族，最初来源于甜艾草 ( Artemisia annua )。除了作为一线抗疟药物的明确作用外，青蒿素还因其其他潜在的药物作用而受到越来越多的关注，包括抗病毒、抗寄生虫、抗真菌、抗炎和抗癌活性。随着进一步临床前和临床研究的共同努力，青蒿素类药物有可能成为治疗多种人类疾病的可行方法。在这里，我们全面更新了青蒿素在其广为人知的抗疟作用之外的药理作用和应用的最新报道，并强调了它们对各种疾病的潜在治疗可行性。