ATG8 are core autophagy proteins, the lipidated forms of which decorate double-membraned autophagosomes, as well as single-membraned organelles such as endolysosomes. Recent studies from the Florey and Münz laboratories delineate the status of single membrane-associated ATG8 proteins by indicating that their membrane anchoring can involve phosphatidylserine conjugation and their stabilization depends on ATG4 protease inhibition.

中文翻译：

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单膜相关 ATG8 蛋白的脂化状态

ATG8 是核心自噬蛋白，其脂质化形式装饰双膜自噬体，以及单膜细胞器，如内溶酶体。Florey 和 Münz 实验室最近的研究表明，单膜相关 ATG8 蛋白的膜锚定可能涉及磷脂酰丝氨酸结合，并且它们的稳定性取决于 ATG4 蛋白酶抑制，从而描绘了它们的状态。