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Transition-Metal Catalyzed Stereoselective Desymmetrization of Prochiral Cyclohexadienones
The Chemical Record ( IF 6.6 ) Pub Date : 2021-06-19 , DOI: 10.1002/tcr.202100136
Anandarao Munakala 1, 2 , Mandalaparthi Phanindrudu 1 , Rambabu Chegondi 1, 2
Affiliation  

The development of transition-metal catalyzed enantioselective and diastereoselective transformations has contributed many advances in the field of synthetic organic chemistry. Particularly, stereoselective desymmetrization of prochiral cyclohexadienones represents a powerful strategy for accessing highly functionalized and stereochemically enriched scaffolds, which are often found in biologically active compounds and natural products. In recent years, several research groups including our group have made a significant progress on transition-metal catalyzed stereoselective desymmetrizations of 2,5-cyclohexadienones. In this account, we will provide an overview of the recent developments in this area employing Pd, Cu, Rh, Au, Ag, Ni, Co, and Mn-catalysts.

中文翻译:

前手性环己二酮的过渡金属催化立体选择性去对称化

过渡金属催化的对映选择性和非对映选择性转化的发展在合成有机化学领域做出了许多进展。特别是,前手性环己二烯酮的立体选择性去对称化代表了一种强大的策略,可用于获取高度功能化和立体化学丰富的支架,这些支架通常存在于生物活性化合物和天然产物中。近年来,包括本课题组在内的多个研究小组在过渡金属催化的2,5-环己二烯酮立体选择性去对称化方面取得了重大进展。在这篇文章中,我们将概述该领域使用 Pd、Cu、Rh、Au、Ag、Ni、Co 和 Mn 催化剂的最新发展。
更新日期:2021-06-19
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