Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels,Journal of Diabetes and its Complications

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Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels
Journal of Diabetes and its Complications ( IF 3 ) Pub Date : 2021-06-19 , DOI: 10.1016/j.jdiacomp.2021.107974
Patricia Pulido-Perez ₁ , Enrique Torres-Rasgado ₂ , Ricardo Pérez-Fuentes ₃ , José Luis Rosales-Encina ₄ , Jorge Rodríguez-Antolín ₅ , Jose R Romero ₆

Affiliation

Doctorate in Biological Science, Autonomous University of Tlaxcala, Mexico; Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA; Center for Biomedical Research East, Mexican Social Security Institute of Puebla, Mexico; Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, National Polytechnic Institute, Mexico.
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA; Center for Biomedical Research East, Mexican Social Security Institute of Puebla, Mexico; Faculty of Medicine, Autonomous University of Puebla, Mexico.
Center for Biomedical Research East, Mexican Social Security Institute of Puebla, Mexico; Faculty of Medicine, Autonomous University of Puebla, Mexico.
Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, National Polytechnic Institute, Mexico.
Tlaxcala Center for Biology of Behavior, Autonomous University of Tlaxcala, Mexico.
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Background

Evidence implicates tumor necrosis factor (TNF) in the pathophysiology of Type 2 Diabetes (T2D) through unclear mechanisms. We hypothesized that disordered glycemic control leads to TNF activation and increases in soluble-TNF (sTNF) and its receptors-1 (sTNFR1) and -2 (sTNFR2).

Methods

We characterized 265 T2D and non-diabetic Latin American subjects and assessed the relationship between the TNF system and fasting plasma glucose (FPG), hemoglobin-A1C (A1C), insulin (FPI), C-peptide and HOMA-Beta.

Results

sTNF and sTNFR2 but not sTNFR1 levels were higher in T2D than non-diabetics (P < 0.0001). In T2D, sTNFR2 was associated with A1C and C-peptide (R² = 0.354, b = 0.504, P < 0.0001; b = 0.167, P = 0.049). Also, T2D patients with disordered glycemic control had increased sTNFR2 levels that correlated with FPG (Rho:0.393, P < 0.001), A1C (Rho:0.451, P < 0.001) and HOMA-Beta (Rho:-0.308, P = 0.005); events not observed in T2D patients with adequate glycemic control. Furthermore, sex-based comparative analyses of T2D patients showed that women compared to men had higher sTNFR2 levels (P = 0.017) that correlated with FPG, A1C, FPI and HOMA-Beta.

Conclusions

Disordered glycemic control is associated with sTNF and sTNFR2. sTNFR2 levels were higher in T2D women than men. Thus, increased sTNFR2 levels may be an important biomarker for disordered glucose and inflammatory complications in T2D patients and women in particular.

中文翻译：

2 型糖尿病女性血糖控制紊乱与 TNF 受体 2 水平升高有关

背景

证据表明肿瘤坏死因子 (TNF) 在 2 型糖尿病 (T2D) 的病理生理学中通过不明确的机制参与。我们假设无序的血糖控制会导致 TNF 活化并增加可溶性 TNF (sTNF) 及其受体-1 (sTNFR1) 和 -2 (sTNFR2)。

方法

我们对 265 名 T2D 和非糖尿病拉丁美洲受试者进行了表征，并评估了 TNF 系统与空腹血糖 (FPG)、血红蛋白-A1C (A1C)、胰岛素 (FPI)、C-肽和 HOMA-Beta 之间的关系。

结果

T2D 患者的 sTNF 和 sTNFR2 而不是 sTNFR1 水平高于非糖尿病患者（P < 0.0001）。在 T2D 中，sTNFR2 与 A1C 和 C 肽相关（R ² = 0.354，b = 0.504，P < 0.0001；b = 0.167，P = 0.049）。此外，血糖控制紊乱的 2 型糖尿病患者 sTNFR2 水平升高，与 FPG (Rho:0.393, P < 0.001)、A1C (Rho:0.451, P < 0.001) 和 HOMA-Beta (Rho:-0.308, P = 0.005); 在血糖控制良好的 T2D 患者中未观察到事件。此外，对 T2D 患者的基于性别的比较分析表明，女性与男性相比具有更高的 sTNFR2 水平 ( P = 0.017)，这与 FPG、A1C、FPI 和 HOMA-Beta 相关。