Aims

Hospitalized patients with diabetes are have an impaired ability to detect hypoglycemia events. The purpose of this study was to compare hypoglycemia symptom scores (HSS) in hospitalized patients with diabetes after a documented blood glucose (BG) <70 mg/dl with recalled HSS with outpatient hypoglycemia events.

Methods

Non-critically ill hospitalized patients with diabetes grouped as symptomatic (n = 23) or asymptomatic (n = 32) at time of index hypoglycemia completed a standardized HSS-Questionnaires (HSS-Q) related to the inpatient event and to recall of symptoms with outpatient hypoglycemia.

Results

After controlling for BG at time of index hypoglycemia (49.8 ± 11.4 vs. 57.4 ± 6.8 mg/dl, p = 0.02), symptomatic patients reported higher HSS than asymptomatic patients with the inpatient event (11.6 ± 7.3 vs. 1.5 ± 3.4, p < 0.001) and in the outpatient setting (13.9 ± 8.6 vs. 10.1 ± 10.6, p < 0.01). Recurrent hypoglycemia was more frequent in asymptomatic patients (13% vs. 44%, p = 0.015) during the hospitalization.

Conclusions

Compared to symptomatic patients, asymptomatic patients had lower inpatient and outpatient HSS and more frequent recurrent hypoglycemia events. These results suggest modification of glycemic management strategies in high risk patients to reduce risk for hypoglycemia events.

中文翻译：

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住院糖尿病患者的低血糖症状减轻

目标

住院的糖尿病患者检测低血糖事件的能力受损。本研究的目的是比较有记录的血糖 (BG) <70 mg/dl 的住院糖尿病患者的低血糖症状评分 (HSS) 与门诊低血糖事件的召回 HSS。

方法

在指数低血糖发生时分为有症状（ n  =  23）或无症状（n  = 32）的非危重住院糖尿病患者 完成了与住院事件相关的标准化 HSS 问卷（HSS-Q）并回忆与门诊低血糖。

结果

在指数低血糖时控制 BG 后（49.8  ±  11.4 vs. 57.4  ±  6.8  mg/dl，p  =  0.02），有症状患者报告的 HSS 高于住院事件的无症状患者（11.6  ±  7.3 vs. 1.5  ±  3.4，p  <  0.001) 和门诊设置 (13.9  ±  8.6 vs. 10.1  ±  10.6, p  <  0.01)。住院期间，无症状患者的低血糖复发率更高（13% vs. 44%，p  =  0.015）。

结论

与有症状的患者相比，无症状患者的住院和门诊 HSS 较低，并且复发性低血糖事件更频繁。这些结果表明对高危患者的血糖管理策略进行了修改，以降低低血糖事件的风险。