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Lung inflammation and simulated airway resistance in infants with cystic fibrosis
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-06-19 , DOI: 10.1016/j.resp.2021.103722
Emily M DeBoer 1 , Julia S Kimbell 2 , Kaci Pickett 3 , Joseph E Hatch 2 , Kathryn Akers 4 , John Brinton 5 , Graham L Hall 6 , Louise King 7 , Fiona Ramanauskas 7 , Tim Rosenow 8 , Stephen M Stick 8 , Harm A Tiddens 9 , Thomas W Ferkol 4 , Sarath C Ranganathan 7 , Stephanie D Davis 2 ,
Affiliation  

Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance. Central airway models with a median of 51 bronchial outlets per model (interquartile range 46,56) were created from chest computed tomography scans of 18 infants with CF and 7 controls. Steady state airflow into the trachea was simulated to estimate central airway resistance in each model. Airway resistance was increased in the full airway models of infants with CF versus controls and in models trimmed to 33 bronchi. Airway resistance was associated with markers of inflammation in bronchoalveolar lavage fluid obtained approximately 8 months earlier but not with markers obtained at the same time. In conclusion, airway resistance estimated by CFD modeling is increased in infants with CF compared to controls and may be related to early airway inflammation.



中文翻译:

囊性纤维化婴儿的肺部炎症和模拟气道阻力

囊性纤维化(CF)的特点是小气道疾病;但中央气道也可能受到影响。我们假设 CF 婴儿的计算流体动力学 (CFD) 方法估计的气道阻力高于对照组,并且 CF 婴儿的早期气道炎症与气道阻力有关。每个模型中位数为 51 个支气管出口的中央气道模型(四分位距 46,56)由 18 名 CF 婴儿和 7 名对照的胸部计算机断层扫描创建。模拟进入气管的稳态气流以估计每个模型中的中央气道阻力。与对照组相比,CF 婴儿的全气道模型和修剪至 33 个支气管的模型的气道阻力增加。气道阻力与大约 8 个月前获得的支气管肺泡灌洗液中的炎症标志物相关,但与同时获得的标志物无关。总之,与对照组相比,CFD 模型估计的气道阻力在 CF 婴儿中增加,并且可能与早期气道炎症有关。

更新日期:2021-07-01
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