ABSTRACT

The solubility of paracetamol in the ternary mixtures of water + ethanol + glycerol at 298.2 and 303.2 K is determined via the shake-flask method. The reported data extend the solubility database for paracetamol in various solvent mixtures and also is employed to investigate the prediction capability of the cosolvency models for solubility prediction in the sub-binary and the ternary solvent systems. The solubility data are correlated with some cosolvency models and their accuracies are evaluated by the mean relative deviation (MRD) computed for back-calculated solubilities. The results show that the investigated models fit well and can be applied to the ternary solvent system, and the experimental data is relatively more consistent with the calculated values. The prediction ability of the trained Jouyban-Acree model for predicting drug solubility behaviour in the corresponding sub-binary systems is also investigated.

摘要

对乙酰氨基酚在 298.2 和 303.2 K 的水 + 乙醇 + 甘油三元混合物中的溶解度通过摇瓶法测定。报告的数据扩展了扑热息痛在各种溶剂混合物中的溶解度数据库，也用于研究共溶解模型在亚二元和三元溶剂系统中的溶解度预测能力。溶解度数据与一些共溶解度模型相关，它们的准确性通过平均相对偏差（MRD) 为反向计算的溶解度计算。结果表明，所研究的模型拟合良好，可应用于三元溶剂体系，实验数据与计算值相对较为一致。还研究了经过训练的 Jouyban-Acree 模型在相应子二元系统中预测药物溶解性行为的预测能力。