Decreased pain sensitivity and alterations of cerebrospinal fluid and plasma inflammatory mediators after total hip arthroplasty in patients with disabling osteoarthritis,Pain Practice

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Decreased pain sensitivity and alterations of cerebrospinal fluid and plasma inflammatory mediators after total hip arthroplasty in patients with disabling osteoarthritis
Pain Practice ( IF 2.6 ) Pub Date : 2021-06-18 , DOI: 10.1111/papr.13051
Martin F Bjurström _{1,

2,

3} , Mikael Bodelsson _{1,

2} , Michael R Irwin ₃ , Camilla Orbjörn ₄ , Oskar Hansson _{4,

5} , Niklas Mattsson-Carlgren _{4,

6,

7}

Affiliation

Proinflammatory mechanisms are implicated in pain states. Recent research indicates that patients with osteoarthritis (OA) with signs of central sensitization exhibit elevated cerebrospinal fluid (CSF) levels of interferon gamma-induced protein 10 (IP-10), Fms-related tyrosine kinase 1 (Flt-1), and monocyte chemoattractant protein 1 (MCP-1).

中文翻译：

致残性骨关节炎患者全髋关节置换术后疼痛敏感性降低以及脑脊液和血浆炎症介质的改变

促炎机制与疼痛状态有关。最近的研究表明，具有中枢致敏迹象的骨关节炎 (OA) 患者的脑脊液 (CSF) 中干扰素 γ 诱导蛋白 10 (IP-10)、Fms 相关酪氨酸激酶 1 (Flt-1) 和单核细胞水平升高趋化蛋白 1 (MCP-1)。

更新日期：2021-06-18

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