Abstract

On our ongoing searching for bioactive natural products derived from entophytes, two polyketides possessing novel skeletons, alternatones A–B (1–2), were identified from the culture of Alternaria alternate L-10. Their structures were established by a combination of spectroscopic and single-crystal X-ray diffraction with Cu Ka radiation. Alternatone A (1) exhibited cytotoxic activity against human hepatoma carcinoma HepG-2 cell line. The putative biosynthetic pathways for compounds 1–2 were also proposed.

中文翻译：

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Alternatones A 和 B，两种聚酮化合物，具有来自内生菌 Alternaria 的新骨架，交替 L-10

摘要

在我们不断寻找来自内生菌的生物活性天然产物的过程中，从链格孢L-10的培养物中鉴定出两种具有新型骨架的聚酮化合物 A-B ( 1-2 ) 。它们的结构是通过光谱和单晶 X 射线衍射与 Cu K a辐射的组合建立的。Alternatone A ( 1 ) 对人肝癌 HepG-2 细胞系表现出细胞毒活性。还提出了化合物1-2的推定生物合成途径。