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Vaccine development against Helicobacter pylori: from ideal antigens to the current landscape
Expert Review of Vaccines ( IF 6.2 ) Pub Date : 2021-06-30 , DOI: 10.1080/14760584.2021.1945450
Irineu Dos Santos Viana 1 , Maria Luísa Cordeiro Santos 2 , Hanna Santos Marques 1 , Vinícius Lima de Souza Gonçalves 1 , Breno Bittencourt de Brito 2 , Filipe Antônio França da Silva 2 , Natália Oliveira E Silva 2 , Fillipe Dantas Pinheiro 2 , Adriano Fernandes Teixeira 2 , Davi Tanajura Costa 2 , Briza Oliveira Souza 2 , Cláudio Lima Souza 2 , Márcio Vasconcelos Oliveira 2 , Fabrício Freire de Melo 2
Affiliation  

ABSTRACT

Introduction: The interest of the world scientific community for an effective vaccine against Helicobacter pylori infection arises from its high prevalence and association with many diseases. Moreover, with an immunological response that is not always effective for the eradication of the bacteria and an increasing antibiotic resistance in the treatment of this infection, the search for a vaccine and new therapeutic modalities to control this infection is urgent.

Areas covered: We bring an overview of the infection worldwide, discussing its prevalence, increasing resistance to antibiotics used in its therapy, in addition to the response of the immune system to the infection registered so far. Moreover, we address the most used antigens and their respective immunological responses expected or registered up to now. Finally, we address the trials and their partial results in development for such vaccines.

Expert opinion: Although several studies for the development of an effective vaccine against this pathogen are taking place, many are still in the preclinical phase or even without updated information. In this sense, taking into account the high prevalence and association with important comorbidities, the interest of the pharmaceutical industry in developing an effective vaccine against this pathogen is questioned.



中文翻译:

幽门螺杆菌疫苗开发:从理想抗原到当前形势

摘要

简介:世界科学界对有效的幽门螺杆菌感染疫苗的兴趣源于其高流行率和与许多疾病的关联。此外,由于免疫反应对于根除细菌并不总是有效,并且在治疗这种感染时抗生素耐药性增加,因此迫切需要寻找一种疫苗和新的治疗方式来控制这种感染。

涵盖的领域:除了免疫系统对迄今为止登记的感染的反应外,我们对全球感染进行了概述,讨论了其流行程度、对治疗中使用的抗生素的耐药性增加。此外,我们还解决了迄今为止预期或注册的最常用的抗原及其各自的免疫反应。最后,我们讨论了此类疫苗开发中的试验及其部分结果。

专家意见:尽管正在开展几项开发针对这种病原体的有效疫苗的研究,但许多仍处于临床前阶段,甚至没有更新信息。从这个意义上说,考虑到高患病率和与重要合并症的关联,制药行业对开发针对这种病原体的有效疫苗的兴趣受到质疑。

更新日期:2021-09-07
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