Functionalized nucleobases are utilized in a wide range of fields; therefore, the development of new synthesis methods is essential for their continued application. With respect to the C⁶-arylation of halopurines, which possess a substituent at the N⁷-position, only a small number of successful cases have been reported, which is predominately a result of large steric hinderance effects. Herein, we report efficient and metal-free C⁶-arylations and S_NAr reactions of N⁷-substituted chloropurines in aromatic and heteroatom nucleophiles promoted by triflimide (Tf₂NH) in fluoroalcohol.

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中文翻译：

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Triflimide 促进的卤代嘌呤的亲核 C-芳基化以获取 N7-取代的嘌呤联芳基

功能化的核碱基被用于广泛的领域；因此，开发新的合成方法对其继续应用至关重要。对于在N ⁷位具有取代基的卤嘌呤的C ⁶芳基化，仅报道了少量成功案例，这主要是大空间位阻效应的结果。在此，我们报告了由氟代醇中的三氟甲磺酸酯 (Tf ₂ NH)促进的芳香族和杂原子亲核试剂中N ⁷取代的氯嘌呤的高效且无金属的C ^{6 -}芳基化和S _N Ar 反应。

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