Journal of Structural Chemistry ( IF 0.8 ) Pub Date : 2021-06-18 , DOI: 10.1134/s0022476621050176 G. -Q. Fu , Y. Fang , J. -J. Yao , B. Ren , X. -F. Zan , E. -L. Liu , M. -J. Chen
Abstract
By the reaction of a rigid π-conjugated H4L linker (5,5′-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2-7-diyl)bis-1,3-benzenedicarboxylic acid), Cu(NO3)2, and N-donor auxiliary linkers, two new Cu-based coordination polymers (CPs), namely {[Cu(L)0.5(1,4-bib)(H2O)2]·0.5H2O}n (1) and {[Cu(H2L)(4,4′-bibp)(H2O)2]}n (2) {1,4-bib = 1,4-bis(1-imidazolyl)benzene, 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl} are synthesized under solvothermal conditions and characterized. Furthermore, the protective effect of compounds 1 and 2 on the sepsis mice model is evaluated and the related mechanism is explored. Firstly, the CFU counting assay is performed to detect the bactericidal effect of compounds 1 and 2 in vivo. Then, the ELISA assay is conducted to measure the release of interleukin-1β (IL-1β) and interleukin-6 (IL-6) into the plasma after treatment with the compounds.
中文翻译:
两种混合配体 Cu(II) 配位聚合物:通过减少过度炎症反应对脓毒症的保护作用
摘要
通过刚性 π-共轭 H 4 L 接头 (5,5'-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2-7-diyl)bis-1 的反应,3-苯二羧酸)、Cu(NO 3 ) 2和N-供体辅助接头,两种新的基于铜的配位聚合物 (CP),即 {[Cu(L) 0.5 (1,4-bib)(H 2 O) 2 ]·0.5H 2 O} n ( 1 ) 和 {[Cu(H 2 L)(4,4'-bibp)(H 2 O) 2 ]} n ( 2) {1,4-bib = 1,4-双(1-咪唑基)苯,4,4'-bibp = 4,4'-双(咪唑基)联苯}在溶剂热条件下合成并表征。此外,还评估了化合物1和2对脓毒症小鼠模型的保护作用,并探讨了相关机制。首先,进行CFU计数测定以检测化合物1和2在体内的杀菌作用。然后,进行ELISA测定以测量用化合物处理后白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)释放到血浆中。