lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking %, ), which is coexpressed with the potential oncogene GALNT8 (Spearman , , TCGA dataset ). Experimental data revealed that GAU1 regulates the expression of GALNT8. The overexpression of either GAU1 or GALNT8 significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC (), while silencing of GAU1 or GALNT8 suppressed the cancer cell proliferation and induced the CRC cell line resistance to oxaliplatin in vitro treatment. Our results suggested that the previously less studied GAU1 and GALNT8 may play as CRC prognosis markers and potential targets for chemotherapy treatment.

中文翻译：

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lncRNA GAU1 诱导 GALNT8 过表达并促进结直肠癌进展

lncRNA 是生物过程中的关键表观遗传调控因子。在人类癌症转录组文库 MiTranscriptome 中，我们通过样本集富集分析（过表达排序）将GAU1鉴定为结直肠癌（CRC）中上调最高的 lncRNA%, )，它与潜在的致癌基因GALNT8 (Spearman, , TCGA 数据集）。实验数据表明， GAU1调节的表达GALNT8。GAU1或GALNT8的过表达显着促进了 CRC 细胞系的细胞周期和增殖，并与 CRC 患者的不良预后相关。)，而GAU1或GALNT8 的沉默抑制癌细胞增殖并诱导 CRC 细胞系对奥沙利铂的体外治疗耐药。我们的结果表明，以前研究较少的GAU1和GALNT8可能作为 CRC 预后标志物和化疗治疗的潜在靶点。