Abstract

Poly(oxanorbornene)s with zinc(II) phthalocyanine side chains have been synthesized by ring-opening metathesis polymerization. The incorporation of zinc(II) phthalocyanine into cationic polymer has given poly(oxanorbornene)s noteworthy photophysicochemical properties and the capacity to generate singlet oxygen under light irradiation. To investigate photosensitizer’s properties of the newly synthesized polymers P6 and P7: fluorescence (Φ_F), singlet oxygen (Φ_Δ) and triplet (Φ_T) quantum yields of polymers have been measured in dimethyl sulfoxide and aqueous medium. Singlet oxygen quantum yields of P6 and P7 have been found to be 0.22 and 0.20 in dimethyl sulfoxide, respectively. Then, photodynamic therapy activities of polymers (P1-P7) against human breast adenocarcinoma cell line (MCF-7 cells) have been investigated. The copolymer P5 bearing pendant zinc(II) phthalocyanine and triethyl phosphonium functionalities has showed enhanced PDT activity with less than 10% viable cells at 60 μg/mL.

摘要

已经通过开环复分解聚合合成了具有锌（II）酞菁侧链的聚（氧代降冰片烯）。将锌（II）酞菁掺入阳离子聚合物中赋予了聚（氧杂降冰片烯）值得注意的光物理化学性质和在光照射下产生单线态氧的能力。为了研究新合成的聚合物P6和P7 的光敏剂特性：在二甲基亚砜和水性介质中测量了聚合物的荧光 (Φ _F )、单线态氧 (Φ _Δ ) 和三线态 (Φ _T ) 量子产率。P6和P7 的单线态氧量子产率已发现在二甲亚砜中分别为 0.22 和 0.20。然后，研究了聚合物（P1-P7）对人乳腺腺癌细胞系（MCF-7细胞）的光动力治疗活性。带有侧链酞菁锌 (II) 和三乙基鏻官能团的共聚物P5显示出增强的 PDT 活性，60 μg/mL 时活细胞少于 10%。