In this Perspective Letter, we discuss the field of remote photonic bio-sensing and diagnosis while focusing on sensing involving spatial analysis of temporally varied defocused secondary speckle patterns. Collecting secondary speckle patterns that were back-reflected from an inspected tissue while properly defocusing the imaging lens allows us to measure nano-vibrations occurring in the tissue. The nano-vibration signal can serve as the common denominator for simultaneous estimation of many bio-medical parameters related to vital bio-signs, hematology, and hemodynamics. This can provide a powerful tool for comprehensive medical diagnosis.

中文翻译：

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远程光子生物传感与诊断展望

在这封透视信中，我们讨论了远程光子生物传感和诊断领域，同时重点关注涉及随时间变化的散焦二级散斑图案的空间分析的传感。收集从被检查组织反射回来的二次散斑图案，同时适当地散焦成像镜头，使我们能够测量组织中发生的纳米振动。纳米振动信号可以作为同时估计与重要生物体征、血液学和血液动力学相关的许多生物医学参数的公分母。这可以为全面的医学诊断提供强大的工具。