Nutrient availability and the cell cycle are known to affect chromatin accessibility. A fundamental question is which mechanisms are involved in connecting nutrient levels, the cell cycle and chromatin regulation. In this issue, Zhang et al. reveal a signalling cascade whereby nutrient-sensing mTORC1 activates the cell-cycle regulator CDK2, thus leading to nuclear translocation of the metabolic enzyme triosephosphate isomerase 1 (TPI1). In the nucleus, TPI1 alters the levels of acetate and global histone acetylation through the metabolite dihydroxyacetone phosphate.

中文翻译：

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提示组蛋白乙酰化的平衡

众所周知，营养物质的可用性和细胞周期会影响染色质的可及性。一个基本问题是哪些机制涉及连接营养水平、细胞周期和染色质调节。在这个问题上，张等人。揭示了一种信号级联，其中营养感应 mTORC1 激活细胞周期调节剂 CDK2，从而导致代谢酶磷酸丙糖异构酶 1 (TPI1) 的核易位。在细胞核中，TPI1 通过代谢物磷酸二羟基丙酮改变乙酸盐和整体组蛋白乙酰化水平。