Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic predisposition. Genome-wide association studies (GWAS) of SLE have identified more than 50 robust susceptibility loci. However, traditional individual SNP-based GWAS have made it difficult to identify variants with small effects. Moreover, variants revealed by GWAS only explain a limited disease heritability, suggesting that many susceptibility genes remain uncovered.

中文翻译：

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基于基因的关联分析确定了一个与系统性红斑狼疮相关的新基因

系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，具有很强的遗传倾向。SLE 的全基因组关联研究 (GWAS) 已经确定了 50 多个强大的易感基因座。然而，传统的基于个体 SNP 的 GWAS 难以识别影响较小的变异。此外，GWAS 揭示的变异仅解释了有限的疾病遗传性，这表明许多易感基因仍未被发现。