Abstract

Purpose

Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios.

Materials and methods

For the dicentric chromosome assay (DCA), blood tubes were located at anthropomorphic phantoms positioned in different geometries and were irradiated with a 1.36 TBq ¹⁹²Ir-source. For each exposure condition, dose estimates were provided by at least one laboratory and for four conditions by 17 participating RENEB laboratories. Three radio-photoluminescence glass dosimeters were placed at each tube to assess reference doses.

Results

The DCA results were homogeneous between participants and matched well with the reference doses (≥95% of estimates within ±0.5 Gy of the reference). For samples close to the source systematic underestimation could be corrected by accounting for exposure time. Heterogeneity within and between tubes was detected for reference doses as well as for DCA doses estimates.

Conclusions

The participants were able to successfully estimate the doses and to provide important information on the exposure scenarios under conditions closely resembling a real-life situation.

中文翻译：

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RENEB/EURADOS 2019 年实地演练：基于双着丝粒染色体分析的室外条件下稳健的剂量估计

摘要

目的

回顾性剂量测定的生物和/或物理分析是恢复暴露情况和辅助医疗决策的宝贵工具。为了进一步验证和改进此类生物和物理分析，2019 年，EURADOS 第 10 工作组和 RENEB 在瑞典隆德进行了实地演练，以模拟各种现实生活中的暴露场景。

材料和方法

对于双着丝粒染色体测定 (DCA)，血管位于不同几何形状的拟人模型上，并用 1.36 TBq ¹⁹² Ir 源照射。对于每种暴露条件，剂量估计值由至少一个实验室提供，四种条件由 17 个参与的 RENEB 实验室提供。三个放射光致发光玻璃剂量计被放置在每个管子上以评估参考剂量。

结果

DCA 结果在参与者之间是同质的，并且与参考剂量匹配良好（在参考剂量的 ±0.5 Gy 内≥95% 的估计值）。对于接近源的样本，可以通过考虑暴露时间来纠正系统低估。对于参考剂量以及 DCA 剂量估计，检测了管内和管之间的异质性。

结论

参与者能够成功地估计剂量，并在与现实生活情况非常相似的条件下提供有关暴露场景的重要信息。